MET tyrosine kinase inhibitor SAR125844

{
  "id": "MLC-T-ONC-015113",
  "term": "MET tyrosine kinase inhibitor SAR125844",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/met-tyrosine-kinase-inhibitor-sar125844/"
}