Cabazitaxel

{
  "id": "MLC-T-ONC-001318",
  "term": "Cabazitaxel",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with prednisone to treat prostate cancer that has spread to other parts of the body and is castration resistant (has not responded to treatments that lower testosterone levels). It is used in patients who have already been treated with anticancer drugs that included docetaxel. It is also being studied in the treatment of other types of cancer. Cabazitaxel stops cancer cells from growing and dividing and may kill them. It is a type of taxane. Also called Jevtana and taxoid XRP6258.",
    "A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB)."
  ],
  "synonyms": [
    "Jevtana",
    "taxoid XRP6258"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cabazitaxel/"
}