larotaxel

{
  "id": "MLC-T-ONC-014718",
  "term": "larotaxel",
  "field": "Oncology and biomedicine",
  "definition": "A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.",
  "synonyms": [
    "RPR 109881A",
    "RPR 109881"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/larotaxel/"
}