calcium release-activated channels inhibitor RP4010

{
  "id": "MLC-T-ONC-012195",
  "term": "calcium release-activated channels inhibitor RP4010",
  "field": "Oncology and biomedicine",
  "definition": "A calcium (Ca2+) release-activated channel (CRAC) inhibitor, with potential antineoplastic activity. Upon administration, RP4010 binds to and inhibits CRACs, thereby preventing the transport of extracellular Ca2+ into the cell and inhibiting the subsequent activation of Ca2+-mediated signaling and transcription of target genes. CRACs, specialized plasma membrane Ca2+ ion channels composed of the plasma membrane based Orai channels and the endoplasmic reticulum (ER) stromal interaction molecules (STIMs), play key roles in calcium homeostasis and are over-activated in a number of cancer cell types. Aberrant activation of CRACs leads to increased cancer cell proliferation.",
  "synonyms": [
    "CRAC inhibitor RP4010"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/calcium-release-activated-channels-inhibitor-rp4010/"
}