carboxyamidotriazole

{
  "id": "MLC-T-ONC-001422",
  "term": "carboxyamidotriazole",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.",
    "An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis."
  ],
  "abbreviation": "CAI",
  "synonyms": [
    "carboxyamido-triazole",
    "carboxyaminoimidazole"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carboxyamidotriazole/"
}