cancer cell metabolism modulator OMT-111

{
  "id": "MLC-T-ONC-012217",
  "term": "cancer cell metabolism modulator OMT-111",
  "field": "Oncology and biomedicine",
  "definition": "A cancer cell metabolism modulator, with potential antineoplastic activity. Upon administration, OMT-111 inhibits pyruvate dehydrogenase kinase (PDH), resulting in the activation of the citric acid cycle in mitochondria, which leads to the degradation of hypoxia-inducible factor 1-alpha (HIF1A). This may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. OMT-111 may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cancer-cell-metabolism-modulator-omt-111/"
}