Carbon C 14 dacomitinib

{
  "id": "MLC-T-ONC-012271",
  "term": "Carbon C 14 dacomitinib",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of an orally bioavailable small-molecule inhibitor of the epidermal growth factor receptor (erbB or HER) family of tyrosine kinases radiolabeled with carbon-14 with potential antineoplastic and beta-emitting radioisotope activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors. The HER receptor family of tyrosine kinases, often overexpressed by a variety of tumor cell types, may contribute to tumor cell proliferation, differentiation, migration, and survival. Dacomitinib radiolabeled with carbon C-14 may be used as a radiotracer in pharmacological studies of dacomitinib metabolism.",
  "synonyms": [
    "[14C]PF-00299804",
    "carbon C 14 PF-00299804",
    "carbon C-14 dacomitinib"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-14-dacomitinib/"
}