carbon C 14 fluzoparib

{
  "id": "MLC-T-ONC-012273",
  "term": "carbon C 14 fluzoparib",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable radioconjugate composed of fluzoparib, an orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2, radiolabeled with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic profile of fluzoparib. Upon administration of carbon C 14 fluzoparib, fluzoparib targets, binds to and inhibits PARP, which results in the inhibition of tumor cell proliferation and survival. Labeling of fluzoparib with the radioactive tracer carbon C 14 allows for the evaluation of fluzoparib's pharmacokinetic profile, including its absorption, distribution, metabolism and excretion (ADME).",
  "synonyms": [
    "14C-fluzoparib",
    "[14C]-fluzoparib"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-14-fluzoparib/"
}