carbon C14 EGFR inhibitor ASP8273

{
  "id": "MLC-T-ONC-012292",
  "term": "carbon C14 EGFR inhibitor ASP8273",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of ASP8273, an orally available, third-generation, mutant-selective, irreversible epidermal growth factor receptor (EGFR) inhibitor, labeled with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic profile of ASP8273 during positron emission tomography (PET). Upon administration of carbon C 14 ASP8273, ASP8273 targets, covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M mutant form. Labeling of ASP8273 with the radioactive tracer carbon C 14 permits the evaluation of this agent's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME) using PET.",
  "synonyms": [
    "[14C] EGFR inhibitor ASP8273",
    "14C EGFR inhibitor ASP8273",
    "14C ASP8273",
    "[14C]ASP8273"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c14-egfr-inhibitor-asp8273/"
}