carbon C14-labeled carboplatin

{
  "id": "MLC-T-ONC-012293",
  "term": "carbon C14-labeled carboplatin",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the platinum compound carboplatin conjugated to the isotope carbon C 14 (14C-carboplatin), which can potentially be used to predict chemoresistance to carboplatin using accelerator mass spectrometry (AMS). Upon administration of a microdose of 14C-carboplatin, the carboplatin moiety covalently binds to DNA and forms carboplatin-DNA monoadducts. Using AMS, the 14C-carboplatin-DNA monoadducts can be detected and measured. The levels of microdose-induced carboplatin-DNA monoadducts can be used to assess the degree of chemoresistance to carboplatin and can predict cancer response to carboplatin-based chemotherapy. The carboplatin microdose is defined as 1/100 of the pharmacologically effective concentration of carboplatin. Low levels of carboplatin monoadduct formation and increased DNA repair, measured by a decrease in the detection of carboplatin-DNA monoadducts over a given time period, are correlated with increased resistance to platinum-based chemotherapeutics.",
  "synonyms": [
    "14C Carboplatin",
    "carbon-14-labeled carboplatin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c14-labeled-carboplatin/"
}