CARD11-BCL10-MALT1 complex inhibitor XL114

{
  "id": "MLC-T-ONC-012307",
  "term": "CARD11-BCL10-MALT1 complex inhibitor XL114",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the caspase recruitment domain-containing protein 11 (CARD11; CARMA1)-B-cell lymphoma/leukemia 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) complex, with potential antineoplastic activity. Upon oral administration, CARD11-BCL10-MALT1 complex inhibitor XL114 inhibits the CARD11-BCL10-MALT1 complex and the CARD11-BCL10-MALT1 signaling pathway. This prevents the proliferation of susceptible cancer cells. The CARD11-BCL10-MALT1 signaling pathway promotes B- and T-cell lymphoma survival and proliferation.",
  "synonyms": [
    "CARD11-BCL10-MALT1 pathway inhibitor XL114",
    "CARMA1-BCL10-MALT1 pathway inhibitor XL114"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/card11-bcl10-malt1-complex-inhibitor-xl114/"
}