MALT1 inhibitor JNJ-67856633

{
  "id": "MLC-T-ONC-014990",
  "term": "MALT1 inhibitor JNJ-67856633",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), with potential antineoplastic activity. Upon administration, MALT1 inhibitor JNJ-67856633 targets, binds to, and prevents the activity of MALT1. This inhibits MALT1-dependent signaling, reduces interleukin-10 (IL-10) and upregulates interferon (IFN). This results in the inhibition of Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling and nuclear factor kappa B (NF-kB) signaling, induces apoptosis, and inhibits tumor cell growth of MALT1-expressing tumor cells. MALT1 belongs to the caspase family of proteases and is the active component of the CARD11-BCL10-MALT1 (CBM) signaling complex. It plays an essential role in B- and T-lymphocyte activation and is over-activated in certain tumor cells.",
  "synonyms": [
    "mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor JNJ-67856633"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/malt1-inhibitor-jnj-67856633/"
}