CDC7 inhibitor SGR-2921

{
  "id": "MLC-T-ONC-012428",
  "term": "CDC7 inhibitor SGR-2921",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule inhibitor of cell division cycle 7-related protein kinase (CDC7), with potential antineoplastic activity. Upon oral administration, CDC7 inhibitor SGR-2921 targets, binds to and inhibits the activity of CDC7, which may result in an impaired response to replication stress, DNA damage, and the induction of tumor cell apoptosis. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays a key role in DNA replication and DNA damage response by binding to and phosphorylating serine (Ser)-40 and 53 of minichromosome maintenance complex component 2 (MCM2).",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cdc7-inhibitor-sgr-2921/"
}