CDC7 inhibitor TAK-931

{
  "id": "MLC-T-ONC-012429",
  "term": "CDC7 inhibitor TAK-931",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of cell division cycle 7 (cell division cycle 7-related protein kinase; CDC7), with potential antineoplastic activity. Upon administration, TAK-931 binds to and inhibits CDC7; this prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, a serine/threonine kinase and cell division cycle protein, is overexpressed in a variety of cancers and plays a key role in the activation of DNA replication and the regulation of cell cycle progression.",
  "synonyms": [
    "cell division cycle 7 inhibitor TAK-931"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cdc7-inhibitor-tak-931/"
}