PLK1 inhibitor TAK-960

{
  "id": "MLC-T-ONC-016119",
  "term": "PLK1 inhibitor TAK-960",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis.",
  "synonyms": [
    "Polo-like kinase 1 inhibitor TAK-960"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plk1-inhibitor-tak-960/"
}