Volasertib

{
  "id": "MLC-T-ONC-017528",
  "term": "Volasertib",
  "field": "Oncology and biomedicine",
  "definition": "A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.",
  "abbreviation": "PLK-1 inhibitor BI 6727",
  "synonyms": [
    "Polo-like kinase 1 inhibitor BI 6727"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/volasertib/"
}