Polo-like kinase 1 inhibitor NMS-1286937

{
  "id": "MLC-T-ONC-016145",
  "term": "Polo-like kinase 1 inhibitor NMS-1286937",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/polo-like-kinase-1-inhibitor-nms-1286937/"
}