CENP-E inhibitor GSK-923295A

{
  "id": "MLC-T-ONC-012513",
  "term": "CENP-E inhibitor GSK-923295A",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295A binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated mitotic kinesin, plays an essential role in chromosome movement during mitosis and regulates cell-cycle transition from metaphase to anaphase.",
  "synonyms": [
    "centromere-associated protein E inhibitor GSK-923295"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cenp-e-inhibitor-gsk-923295a/"
}