cFMS tyrosine kinase inhibitor ARRY-382

{
  "id": "MLC-T-ONC-012539",
  "term": "cFMS tyrosine kinase inhibitor ARRY-382",
  "field": "Oncology and biomedicine",
  "definition": "A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cfms-tyrosine-kinase-inhibitor-arry-382/"
}