clarithromycin

{
  "id": "MLC-T-ONC-001796",
  "term": "clarithromycin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An antibiotic drug used in the treatment of infections. It belongs to the family of drugs called macrolides.",
    "A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression."
  ],
  "abbreviation": "CLARITH",
  "synonyms": [
    "Abbott-56268"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/clarithromycin/"
}