Cladribine

{
  "id": "MLC-T-ONC-001795",
  "term": "Cladribine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat hairy cell leukemia. It is also being studied in the treatment of other types of cancer. Cladribine damages the cell’s DNA and may kill cancer cells. It is a type of antimetabolite.",
    "A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity."
  ],
  "abbreviation": "2-CdA",
  "synonyms": [
    "cladribina"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cladribine/"
}