Tiazofurin

{
  "id": "MLC-T-ONC-008706",
  "term": "Tiazofurin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug being studied to stop cell growth.",
    "A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo."
  ],
  "abbreviation": "TCAR",
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tiazofurin/"
}