8-chloroadenosine

{
  "id": "MLC-T-ONC-009561",
  "term": "8-chloroadenosine",
  "field": "Oncology and biomedicine",
  "definition": "An antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis.",
  "abbreviation": "8-Cl-Ado",
  "synonyms": [
    "8-chloro-adenosine",
    "8-Cl-adenosine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/8-chloroadenosine/"
}