tocladesine

{
  "id": "MLC-T-ONC-008751",
  "term": "tocladesine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that has been studied as an anticancer drug. It is an analog of a substance that occurs naturally in the body (cyclic adenosine monophosphate).",
    "An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes the endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis."
  ],
  "abbreviation": "8-Cl-cAMP",
  "synonyms": [
    "8-chloro cyclic AMP",
    "ICN-1256",
    "adenazole",
    "cAMP"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tocladesine/"
}