Codrituzumab

{
  "id": "MLC-T-ONC-012694",
  "term": "Codrituzumab",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the cell surface oncofetal protein glypican-3 (GPC3) with potential antineoplastic activity. Anti-GPC3 monoclonal antibody GC33 binds to GPC3 and triggers a host immune response against GPC3-expressing tumor cells, which may result in tumor cell death. GPC3, a heparin sulfate proteoglycan, is frequently upregulated in hepatocellular carcinoma and mesoderm-derived organs such as the liver, lungs, and kidney.",
  "synonyms": [
    "anti-glypican 3 monoclonal antibody GC33"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/codrituzumab/"
}