Colistimethate sodium

{
  "id": "MLC-T-ONC-012701",
  "term": "Colistimethate sodium",
  "field": "Oncology and biomedicine",
  "definition": "The sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect.",
  "synonyms": [
    "colimyscine",
    "colistin sodium methanesulfonate",
    "pentasodium colistinmethanesulfonate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/colistimethate-sodium/"
}