CTLA-4

{
  "id": "MLC-T-ONC-002173",
  "term": "CTLA-4",
  "field": "Oncology and biomedicine",
  "definition": "A protein found on T cells (a type of immune cell) that helps keep the body’s immune responses in check. When CTLA-4 is bound to another protein called B7, it helps keep T cells from killing other cells, including cancer cells. Some anticancer drugs, called immune checkpoint inhibitors, are used to block CTLA-4. When this protein is blocked, the “brakes” on the immune system are released and the ability of T cells to kill cancer cells is increased.",
  "see_also": [
    "immune checkpoint inhibitor"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/ctla-4/"
}