cyclin-dependent kinase 8/19 inhibitor BCD 115

{
  "id": "MLC-T-ONC-012860",
  "term": "cyclin-dependent kinase 8/19 inhibitor BCD 115",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of cyclin dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor BCD 115 binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of certain tumor promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDKs are serine/threonine kinases involved in the regulation of the cell cycle and may be overexpressed in certain cancer cell types. CDK8 plays a key role in transcription regulation and is an important oncogenic driver in a variety of cancer cell types.",
  "synonyms": [
    "CDK8/19 inhibitor BCD 115",
    "CDK 8/19 inhibitor BCD 115"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cyclin-dependent-kinase-8-19-inhibitor-bcd-115/"
}