Dabrafenib

{
  "id": "MLC-T-ONC-012894",
  "term": "Dabrafenib",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.",
  "synonyms": [
    "BRAF inhibitor GSK2118436"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dabrafenib/"
}