denileukin diftitox-cxdl

{
  "id": "MLC-T-ONC-012978",
  "term": "denileukin diftitox-cxdl",
  "field": "Oncology and biomedicine",
  "definition": "A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death.",
  "abbreviation": "DAB389-IL2",
  "synonyms": [
    "DAB389 interleukin-2",
    "DABIL2",
    "DAB389 interleukin-2 immunotoxin",
    "Ontak",
    "DAB(389)-interleukin-2",
    "interleukin-2 fusion protein",
    "interleukin-2 fusion toxin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/denileukin-diftitox-cxdl/"
}