Gastrin immunotoxin

{
  "id": "MLC-T-ONC-013906",
  "term": "Gastrin immunotoxin",
  "field": "Oncology and biomedicine",
  "definition": "An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety.",
  "abbreviation": "G17DT",
  "synonyms": [
    "G17DT immunogen",
    "anti-gastrin 17",
    "neutralize hormone G17",
    "anti-gastrin therapeutic vaccine",
    "neutralizing G17 hormone",
    "PAS"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gastrin-immunotoxin/"
}