[Leu15] gastrin-17

{
  "id": "MLC-T-ONC-014755",
  "term": "[Leu15] gastrin-17",
  "field": "Oncology and biomedicine",
  "definition": "A C-terminal amidated synthetic gastrin analog with a single amino acid change at position 15, where leucine replaces methionine, with potential hypoglycemic and immunomodulatory activities. Following pancreatic islet cell transplantation, subcutaneous administration of [Leu15] gastrin-17 (GAST-17) may induce pancreatic beta cell regeneration and expansion and enhance the insulin secretory capacity of islet cell grafts. Additionally, GAST-17 may reduce inflammation within the islet cell environment, which could potentially improve islet graft survival and function. Gastrin, a gastrointestinal peptide, may induce beta cell neogenesis via induction of the duodenal and pancreatic homeobox transcription factor, PDX-1. Gastrin may also promote beta cell proliferation and neogenesis indirectly through increasing the production of clustrin, a beta cell expansion factor.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/leu15-gastrin-17/"
}