deuterated 3-methylhistidine

{
  "id": "MLC-T-ONC-013000",
  "term": "deuterated 3-methylhistidine",
  "field": "Oncology and biomedicine",
  "definition": "A derivative of the amino acid histidine labeled with heavy hydrogen (D) used in diagnostic procedures. Upon intake of deuterated 3-methylhistidine (3-MH), this agent is incorporated into muscle protein and then is subsequently excreted unchanged in the urine. By measuring the amount of 3-MH in the urine, via analysis of deuterium, the rate of protein muscle catabolism can be determined and the risk of skeletal muscle atrophy or cachexia can be assessed. 3-methylhistidine is a myofibrillar-specific amino acid and is mainly found in muscle myosin and actin; proteolysis of myofibrils releases 3-MH that is excreted unchanged in the urine.",
  "abbreviation": "D-3MH",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/deuterated-3-methylhistidine/"
}