Deuterated phenanthrene

{
  "id": "MLC-T-ONC-013003",
  "term": "Deuterated phenanthrene",
  "field": "Oncology and biomedicine",
  "definition": "A noncarcinogenic and structural analogue of polycyclic aromatic hydrocarbon (PAH), phenanthrene labeled with deuterium ([D10]Phe) with potential use in assessing an individual’s capacity for PAH metabolism by the diol epoxide pathway. Upon oral or inhalation administration, [D10]Phe is metabolized into the tetraol end product ([D10]PheT) via the diol epoxide pathway, and can be quantified in urine. [D10]PheT can be used as a biomarker to assess PAHs metabolic activation and may therefore determine an individual’s susceptibility to carcinogenicity upon PAH exposure.",
  "abbreviation": "[D10]Phe",
  "synonyms": [
    "[D10] phenanthrene",
    "phenanthrene-D10"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/deuterated-phenanthrene/"
}