DNA polymerase theta inhibitor RP-3467

{
  "id": "MLC-T-ONC-013102",
  "term": "DNA polymerase theta inhibitor RP-3467",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of DNA polymerase (pol) theta, with potential chemosensitizing and antineoplastic activities. Upon oral administration, pol theta inhibitor RP-3467 specifically targets, binds to and inhibits the activity of pol theta. This prevents pol theta-mediated repair of double-stranded DNA breaks via the microhomology-mediated end joining (MMEJ) process. This causes apoptosis and inhibits proliferation in cancer cells. RP-3467 may have a synergistic effect if administered in combination with agents that cause DNA damage. Pol theta plays a key role in DNA synthesis and repair that is highly expressed in cancer cells while nearly absent in most healthy tissues. It plays a key role in cancer cell survival.",
  "synonyms": [
    "Pol theta inhibitor RP-3467"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dna-polymerase-theta-inhibitor-rp-3467/"
}