pidnarulex

{
  "id": "MLC-T-ONC-016068",
  "term": "pidnarulex",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of RNA polymerase I (Pol I), with potential antineoplastic activity. Upon oral administration, pidnarulex selectively binds to and inhibits Pol I, prevents Pol I-mediated ribosomal RNA (rRNA) synthesis, induces apoptosis, and inhibits tumor cell growth. Pol I, the multiprotein complex that synthesizes rRNA, is upregulated in cancer cells and plays a key role in cell proliferation and survival. Hyperactivated rRNA transcription is associated with uncontrolled cancer cell proliferation.",
  "synonyms": [
    "Pol I inhibitor CX5461",
    "RNA Pol I inhibitor CX5461"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pidnarulex/"
}