DNR-expressing nasopharyngeal carcinoma-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-013113",
  "term": "DNR-expressing nasopharyngeal carcinoma-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, dominant-negative receptor (DNR)-expressing nasopharyngeal carcinoma (NPC)-specific cytotoxic T-lymphocytes (CTLs), with potential antineoplastic activity. The DNR-expressing NPC-specific CTLs specifically target Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1), latent membrane proteins (LMP) and BamHIA rightward frame 1 (BARF1), and are transduced with a retroviral vector expressing DNR, a dominant-negative form of the transforming growth factor beta (TGFb) receptor, which blocks TGF-beta-mediated signaling. Upon administration, the CTLs recognize and target NPC cells, which may result in both CTL-mediated cell lysis and the inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T-lymphocyte activation and expansion; resistance to TGF-beta allows for optimal CTL activity. EBV infection plays a key role in NPC tumorigenesis.",
  "abbreviation": "DNR NPC-specific CTL",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dnr-expressing-nasopharyngeal-carcinoma-specific-cytotoxic-t-lymphocytes/"
}