EBNA-1 inhibitor VK-2019

{
  "id": "MLC-T-ONC-013199",
  "term": "EBNA-1 inhibitor VK-2019",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, small molecule inhibitor of Epstein-Barr nuclear antigen 1 (EBNA-1) with potential antineoplastic activity. Upon administration, EBNA-1 inhibitor VK-2019 binds to EBNA-1 and inhibits EBNA-1 DNA binding activity. This disrupts the replication, maintenance and segregation of the Epstein-Barr virus (EBV) genome, which may lead to tumor cell death in EBV-associated malignancies. EBNA1, a sequence-specific DNA binding protein, plays an important role in EBV episomal genome maintenance and gene transactivation.",
  "synonyms": [
    "Epstein-Barr nuclear antigen 1 inhibitor VK-2019"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ebna-1-inhibitor-vk-2019/"
}