efatutazone dihydrochloride

{
  "id": "MLC-T-ONC-013217",
  "term": "efatutazone dihydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.",
  "synonyms": [
    "PPAR-gamma agonist CS-7017",
    "inolitazone dihydrochloride"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/efatutazone-dihydrochloride/"
}