quinacrine dihydrochloride

{
  "id": "MLC-T-ONC-016326",
  "term": "quinacrine dihydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.",
  "synonyms": [
    "atabrine dihydrochloride",
    "mepacrine dihydrochoride"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/quinacrine-dihydrochloride/"
}