Efbemalenograstim alfa

{
  "id": "MLC-T-ONC-013219",
  "term": "Efbemalenograstim alfa",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Efbemalenograstim alfa binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy.",
  "synonyms": [
    "recombinant dimeric G-CSF fusion protein F627",
    "Rh G-CSF Fc fusion protein F-627"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/efbemalenograstim-alfa/"
}