Eg5 kinesin-related motor protein inhibitor ARQ 621

{
  "id": "MLC-T-ONC-013233",
  "term": "Eg5 kinesin-related motor protein inhibitor ARQ 621",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor ARQ 621 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein involved in the regulation of spindle dynamics, including assembly and maintenance, during mitosis.",
  "synonyms": [
    "Eg5 inhibitor ARQ 621"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/eg5-kinesin-related-motor-protein-inhibitor-arq-621/"
}