EGFRBi-armed autologous activated T cells

{
  "id": "MLC-T-ONC-013271",
  "term": "EGFRBi-armed autologous activated T cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous activated T cells, loaded with a bispecific antibody produced by heteroconjugation of anti-CD3 and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, with potential antineoplastic activity. Binding of EGFRBi-armed autologous activated T cells to EGFR-positive tumor cells may result in increased T cell-mediated cytotoxicity towards tumor cells expressing EGFR. Arming activated T cells with this bispecific antibody may significantly increase T cell secretion of anti-tumor associated cytokines such as IL2, RANTES, IFN-gamma, and TNF-alpha.",
  "synonyms": [
    "anti-CD3 OKT3/anti-EGFR bispecific antibody armed activated T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egfrbi-armed-autologous-activated-t-cells/"
}