HER2Bi-armed activated T cells

{
  "id": "MLC-T-ONC-014097",
  "term": "HER2Bi-armed activated T cells",
  "field": "Oncology and biomedicine",
  "definition": "Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2 for 14 days and then armed with anti-CD3 × anti-Her2 bispecific antibody (Her2Bi). Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells; this may result in the recruitment and activation of cytotoxic T lymphocytes (CTLs), CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines and chemokines.",
  "abbreviation": "HER2Bi-armed ATCs",
  "synonyms": [
    "anti-CD3 x anti-Her2/neu bispecific antibody-armed activated T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/her2bi-armed-activated-t-cells/"
}