anti-CD3/humanized 3F8 bispecific antibody-activated T lymphocytes

{
  "id": "MLC-T-ONC-010384",
  "term": "anti-CD3/humanized 3F8 bispecific antibody-activated T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous activated T cells that have been coated with bispecific antibodies (BiAb) comprised of anti-CD3 murine monoclonal antibody OKT3 heteroconjugated to anti-GD2 humanized monoclonal antibody 3F8 (hu3F8), with potential antineoplastic and immunomodulating activities. In vitro, T cells are exposed to OKT3, which binds to the T cell receptor-CD3 complex on the T cell surface, crosslinks the CD3 receptors and leads to T cell activation. In turn, the hu3F8 monoclonal antibody is heteroconjugated to OKT3. Upon administration, anti-CD3 x anti-GD2 bispecific antibody-armed activated T cells attach to GD2-expressing tumor cells, thereby selectively cross-linking T cells and tumor cells. This results in selective cytotoxicity towards the GD2-expressing tumor cells. In addition, cytokine and chemokine secretion by the T cells further activates the immune system, which leads to the recruitment and activation of cytotoxic T lymphocytes (CTLs), and additional CTL-mediated tumor-specific cell lysis. GD2, a disialoganglioside and tumor-associated antigen, is overexpressed in a variety of tumor cell types. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction.",
  "abbreviation": "Hu3F8Bi-armed ATC",
  "synonyms": [
    "OKT3/humanized 3F8 bispecific antibody-activated T lymphocytes",
    "anti-CD3 x hu3F8 bispecific antibody-armed ATC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-humanized-3f8-bispecific-antibody-activated-t-lymphocytes/"
}