anti-CD3/CD7-ricin toxin A immunotoxin

{
  "id": "MLC-T-ONC-010383",
  "term": "anti-CD3/CD7-ricin toxin A immunotoxin",
  "field": "Oncology and biomedicine",
  "definition": "An immunotoxin (IT) combination composed of two antibody-drug conjugates (ADCs), one containing a monoclonal antibody against CD3 and one against the CD7 antigen on activated T cells and natural killer (NK) cells, and both conjugated to ricin toxin A (RTA), the A-chain form of the potent plant toxin ricin, that can potentially be used to destroy activated T and NK cells. Upon administration of the anti-CD3/CD7-RTA immunotoxin, the anti-CD3 antibody moiety targets and binds to activated T-cells; the anti-CD7 antibody moiety targets and binds to CD7 on activated T cells and NK cells. Upon internalization and cleavage, the RTA moiety irreversibly inhibits protein synthesis and induces apoptosis in the activated T cells. This may eliminate activated T cells and may improve conditions such as graft-versus-host-disease (GvHD). In addition, the binding and blocking of the anti-CD3 antibody to the T-cell receptor/CD3 complex (TCR/CD3) results in activation-induced cell death (AICD) and immunosuppression.",
  "synonyms": [
    "anti-CD3/CD7-RTA immunotoxin",
    "CD3/CD7-ricin A IT"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-cd7-ricin-toxin-a-immunotoxin/"
}