Di-dgA-RFB4 immunotoxin

{
  "id": "MLC-T-ONC-013045",
  "term": "Di-dgA-RFB4 immunotoxin",
  "field": "Oncology and biomedicine",
  "definition": "An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to two deglycosylated ricin toxin A-chain (Di-dgA). This agent can be extracted from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This Di-dgA conjugated MoAb RFB4 delivers 7 fold more cytotoxicity than the single dgA immunotoxin against CD22-positive malignant cells.",
  "synonyms": [
    "Di-dgA-RFB4 monoclonal antibody",
    "monoclonal antibody Di-dgA-RFB4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/di-dga-rfb4-immunotoxin/"
}