Deglycosylated ricin A chain-conjugated anti-CD19/anti-CD22 immunotoxins

{
  "id": "MLC-T-ONC-012951",
  "term": "Deglycosylated ricin A chain-conjugated anti-CD19/anti-CD22 immunotoxins",
  "field": "Oncology and biomedicine",
  "definition": "A combination preparation of 1:1 mixture of the immunotoxins HD37-dgA and RFB4-dgA with potential antineoplastic activity. Anti-CD19 IgG monoclonal antibody HD37 and anti-CD22 IgG monoclonal antibody RFB4 are attached individually to a deglycosylated ricin A chain (dgA) via N-succinimidyl-oxycarbonyl-alpha-methyl-alpha-(2-pyridyldithio) toluene (SMPT) linker. Deglycosylated ricin A chain-conjugated anti-CD19/anti-CD22 immunotoxins bind to CD19- and CD22-expressing tumor cells, specifically delivering cytotoxic ricin A chain to leukemia cells expressing these antigens. Ricin A chain is toxic to ribosomal activity and protein synthesis, and inhibits cell growth. CD19 and CD22 molecules are cell surface antigens present on the majority of B acute lymphoblastic leukemia (ALL) cells.",
  "synonyms": [
    "IgG-HD37-dgA/IgG-RFB4-dgA immunotoxins"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/deglycosylated-ricin-a-chain-conjugated-anti-cd19-anti-cd22-immunotoxins/"
}