allogeneic anti-CD19/CD22 CAR-BBz T cells

{
  "id": "MLC-T-ONC-009811",
  "term": "allogeneic anti-CD19/CD22 CAR-BBz T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic T lymphocytes that have been transduced with a bivalent lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the two tumor-associated antigens (TAAs) CD19 and CD22, linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19/CD22 CAR-BBz T cells bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies.",
  "synonyms": [
    "allogeneic anti-CD19/anti-CD22 CAR T cells",
    "allogeneic anti-CD19/CD22 CAR T cells",
    "allogeneic anti-CD19/CD22 CAR-T cells",
    "allogeneic CD19/CD22-BBz CAR T cells",
    "allogeneic CD19/CD22-CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd19-cd22-car-bbz-t-cells/"
}