allogeneic anti-CD19-CAR-CD28-IL-15-expressing natural killer T cells

{
  "id": "MLC-T-ONC-009810",
  "term": "allogeneic anti-CD19-CAR-CD28-IL-15-expressing natural killer T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic natural killer T lymphocytes (NKTs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, interleukin 15 (IL-15) and the costimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD19-CAR-CD28-IL-15-expressing NKTs target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. CD28 costimulatory molecule enhances activation and signaling after recognition of CD19, and may increase proliferation of T cells and antitumor activity. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "allogeneic anti-CD19 CAR/IL-15-expressing natural killer T cells",
    "allogeneic anti-CD19-CAR-CD28-IL-15-expressing NKTs",
    "allogeneic anti-CD19-CAR-IL-15-expressing natural killer T cells",
    "CD19.CAR allogeneic NKT cells",
    "CD19.CAR-aNKT cells",
    "CD19.CAR-aNKTs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd19-car-cd28-il-15-expressing-natural-killer-t-cells/"
}